CDMRP Breast Cancer Breakthrough Award Levels 1 and 2

Research supported by the Breakthrough Award will have the potential for a major impact and accelerate progress toward ending breast cancer. The impact may be near-term or long-term, but must be significant and move beyond an incremental advancement. Applications must articulate the pathway to making a clinical impact for individuals with, or at risk for, breast cancer, even if clinical impact is not an immediate outcome.

It is expected that eight (20) awards will be granted for level 1. 

Level 1:
Innovative, high-risk/high-reward research that is in the earliest stages of idea development. Research with potential to yield new avenues of investigation. Proof of concept. No preliminary data required.
Funding: $540,000 total (if submitting with Co-PI $900,000)

Level 2: 
Research that is already supported by preliminary data and has potential to make significant advancements toward clinical translation. Demonstration of efficacy in in vivo models, as applicable.
Funding: $1,200,000 total (if submitting with Co-PI $1,800,000)
Level 2 Population Science and Prevention Studies $1,800,000 (if submitting with Co-PI $2,400,000)

Duration: 3 years; Population Science and Prevention Studies 4 years 

Research Authority due date: 5.6.25
LOI  due date: 13.6.25
Full proposal due date: 27.6.25