CDMRP Tuberous Sclerosis Complex Research Program: Exploration – Hypothesis Development Award

The Exploration – Hypothesis Development Award supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the TSC research field. The studies supported by this award mechanism are expected to lay the groundwork for future avenues of scientific investigation.

Focus Areas:

• Understanding, preventing and treating the features of TSC-associated neuropsychiatric disorders and reducing their impact, including pharmacological, behavioral and surgical interventions.
• Strategies for preventing and eradicating tumors and cysts associated with TSC, such as angiomyolipomas, subependymal giant cell astrocytoma and lymphangioleiomyomatosis (LAM), including gaining a deeper mechanistic understanding of tumor microenvironment, TSC signaling and m-TOR independent pathways.
• Preventing epilepsy, improving treatment and mitigating neurodevelopmental and adverse outcomes associated with TSC-related seizures.
• Developing, assessing and testing emerging diagnostic and therapeutic technologies to improve outcomes in TSC.
• Understanding potential pathogenic mechanisms or improving outcomes of maternal-fetal and reproductive health of women with TSC or LAM and the perinatal care of fetuses or newborns with TSC

It is expected that 6 awards will be granted. 

Funding: $150,000 total
Duration: 2 years

Research Authority due date: 16.7.26

Pre application (required) due date: 23.7.26

Full application due date: 6.8.26