CDMRP Tuberous Sclerosis Complex Research Program: Idea Development Award

The Idea Development Award supports conceptually innovative research that could ultimately lead to critical discoveries in TSC research and/or improvements in patient care. Research projects should include a well-formulated, testable hypothesis based on strong preliminary data and scientific rationale.

The program offers separate tracks for established and new investigators 

Focus Areas:

• Understanding, preventing and treating the features of TSC-associated neuropsychiatric disorders and reducing their impact, including pharmacological, behavioral and surgical interventions.
• Strategies for preventing and eradicating tumors and cysts associated with TSC, such as angiomyolipomas, subependymal giant cell astrocytoma and lymphangioleiomyomatosis (LAM), including gaining a deeper mechanistic understanding of tumor microenvironment, TSC signaling and m-TOR independent pathways.
• Preventing epilepsy, improving treatment and mitigating neurodevelopmental and adverse outcomes associated with TSC-related seizures.
• Developing, assessing and testing emerging diagnostic and therapeutic technologies to improve outcomes in TSC.
• Understanding potential pathogenic mechanisms or improving outcomes of maternal-fetal and reproductive health of women with TSC or LAM and the perinatal care of fetuses or newborns with TSC

It is expected that 4 awards will be granted.

Funding: $800,000 total.
Duration: 3 years

Research Authority due date:  16.7.26

Pre application (required) due date: 23.7.26

Full application due date: 68.26