CDMRP Breast Cancer Breakthrough Award Levels 1 and 2

Research supported by the Breakthrough Award will have the potential for a major impact and accelerate progress toward ending breast cancer. The impact may be near-term or long-term, but must be significant and move beyond an incremental advancement. Applications must articulate the pathway to making a clinical impact for individuals with, or at risk for, breast cancer, even if clinical impact is not an immediate outcome.

It is expected that 18 awards will be granted. 

Level 1:
Innovative, high-risk/high-reward research that is in the earliest stages of idea development. Research with potential to yield new avenues of investigation. Proof of concept. No preliminary data required.
Funding: $750,000 total (if submitting with Co-PI $1,250,000)

Level 2: 
Research that is already supported by preliminary data and has potential to make significant advancements toward clinical translation. Demonstration of efficacy in in vivo models, as applicable.
Funding: $1,650,000 total (if submitting with Co-PI $2,500,000)
Level 2 Population Science and Prevention Studies $3,500,000 (if submitting with Co-PI $3,350,000)

Duration: 3 years; Population Science and Prevention Studies 4 years 

Research Authority due date: 18.6.26
​Pre proposal (required)  due date: 24.6.26
Full proposal due date: 8.7.26