2026 MPN Challenge

The primary goal of the MPN Research Foundation’s research strategy is to understand and control the progression of the MPNs from chronic to life-threatening stages. 

In order to do that, we believe our focus should be the elimination of the mutant stem cells which promote these diseases.  

2026 focus areas: 

A) Artificial Intelligence / Machine Learning in MPNs

B) MPL Milestones Program:

• Discovery and development of new drugs targeting MPL-mutated pathways
• Drug repurposing for MPL-driven MPNs
• Studies of disease mechanisms and resistance
• Identification of cooperating mutations that influence disease course or therapy response
• Risk stratification, biomarker development, and real-world outcomes research selection in MPL-mutated MPNs

Funding: $200,000 total 
Duration: 2 years 

Research Authority due date: 16.3.26