Targeted Call in Honour of the life, work and legacy of Prof Charis Eng 2025

Through this call, PTEN Research wishes to honour and build on the work of Prof Eng and invites academic research proposals that aim to progress the understanding of the mechanisms that contribute to the variable clinical presentation of PHTS.

Specifically, we seek research proposals that focus on one of the following aims:

• Explore opportunities to identify and/or undertake preliminary validation of biomarkers for PHTS that could predict symptom onset, occurrence, or progression/severity of symptoms at the individual level.
• Elucidate the mechanisms of clinical heterogeneity that may include assessment of how different PTEN variants and other genetic, molecular, or cellular mechanisms contribute to and are associated with the clinical spectrum associated with PHTS.

Funding: £270,000 total 

Duration: 2-3 years 

Research Authority due date: 18.11.25

Notice of Intent (required) due date: 25.11.25

Full proposal due date: 3.4.25