LCRF Research Grant on Overcoming Resistance in Lung Cancer

This grant mechanism will focus on understanding the development, prevention, and therapy of resistance by supporting projects that are identifying, characterizing, treating or preventing resistance to therapies in lung tumor cells, tissues, mouse models, and/or patients. Areas of interest include:  

• Mechanisms of resistance to targeted therapies for oncogene-driven lung cancers. Proposals are encouraged in the areas of histological transformation, oligometastatic disease, oligo-remnant disease, uncommon mutations and non-genomic mechanisms of resistance.
• Biology and mechanisms of drug resistance to lung cancer therapies including chemotherapy, immunotherapy, radiotherapy, and antibody drug conjugates.
• Novel treatment approaches and new therapies to overcome and/or prevent resistance to lung cancer therapies.
• Novel diagnostic approaches (i.e. biomarkers) to monitor treatment response and relapse.
• Overcoming resistance in difficult to treat sites of metastases such as leptomeningeal and brain metastases.

Funding: $150,000
Duration: 2 years

Research Authority deadline: 24.2.25

LOI (required) due date: 3.3.25

Full proposal due date: 2.6.25