CDMRP Combat Casualty Care Research Program: Trauma Immunology Research Award

The Trauma Immunology Research Award (TIRA) will support basic and applied research and early-stage development of materiel and knowledge products to address critical gaps in the understanding of immune system, immune response, immune function, and other associated host responses in combat injuries, in particular, severe polytrauma as encountered in the operational environment.

FY23 Focus Areas include:

• Studies seeking to understand the initial inflammation and immune response profile to severe polytrauma that involves multiple organs at the molecular, cellular, tissue, and organ level.
• Studies seeking to understand the post traumatic local and systemic immune responses and pathophysiological mechanisms. Of particular interest are studies that seek to understand how the immune response leads to secondary organ damage.
• Early-stage development of potential novel products and knowledge for treating severe polytrauma and associated deleterious immune responses.
• Development and optimization of animal models that mimic the human trauma immunologic response, to improve the understanding of the human immune response and functions during and post severe polytrauma.

It is expected that 5 awards will be granted.