CDMRP Tuberous Sclerosis Complex Research Program: Exploration – Hypothesis Development Award

The Exploration – Hypothesis Development Award supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the TSC research field. The studies supported by this award mechanism are expected to lay the groundwork for future avenues of scientific investigation.

Focus Areas:

• Understanding, preventing, and treating the features of TSC-Associated Neuropsychiatric Disorders (TAND) and reducing their impact, including pharmacological, behavioral, and surgical interventions
• Strategies for eradicating tumors associated with TSC and TSC-associated lymphangioleiomyomatosis (LAM), including gaining a deeper mechanistic understanding for tumor microenvironment, TSC signaling, and mTOR interdependent pathways
• Preventing epilepsy, improving treatment, and mitigating neurodevelopmental and adverse outcomes associated with TSC-related seizures
• Developing, assessing, and testing emerging technologies including imaging and molecular therapeutic strategies, such as gene therapy, to improve outcomes in TSC

It is expected that 5 awards will be granted. 

Funding: $150,000 total
Duration: 2 years

Research Authority due date: 1.6.23

Pre application (required) due date: 8.6.23

Full application due date: 7.7.23