Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase I: Data Analysis and Validation Centers (U01)

The purpose of this grant is to establish state-of-the-art Data Analysis and Validation (DAV) Centers. NHGRI aims to optimize available methods to create null alleles and measure their phenotypic effects in a target subset of 1000 protein coding genes across the program. This phase will also assess the scale limitations of such methods, develop common data formats, establish “use cases” for this catalog, and inform whether and how a potential second phase will be implemented.

Funding: $350,000 per year 

Duration: 5 years

Research Authority due date: 15.9.22

LOI (encouraged) due date: 1.10.22

Full proposal due date: 1.11.22