The Cellular Scale Connectome in Aging and Alzheimer’s Disease (U01)

This grant invites applications that will:

(1) promote the development of a comprehensive characterization of brain circuits susceptible to Alzheimer’s disease type pathology and/or neurodegeneration in mouse models of Alzheimer's disease (AD)

(2) share data on the cell connectome in the aging and AD brain in a common reference brain cell atlas that integrates both molecular and anatomical annotations

(3) complement and extend research on vulnerable cell types to include the mapping of connectivity changes between cells in aging and AD and provide a greater understanding of the mechanisms underlying resilience and vulnerability in AD.

Funding: no fixed limit 

Duration: 5 years

Research Authority due date: 5.5.21

LOI (encouraged) due date: 15.5.21

Full proposal due date: 15.6.21