DARPA (BTO): INTERfering and Co-Evolving Prevention and Therapy

קרןUS Department of Defense
מדינהU.S.A.
סוגResearch Grants
תאריך אחרון07/07/2016
פקולטהEngineering, Exact Sciences, Life Sciences, Medicine
תיאור

 

Current preventive and therapeutic approaches to address viral pathogens are designed to target the virus in its circulating state or at the time of diagnosis. However, pathogens mutate and evolve over time, becoming resistant to many therapies. The goal of the INTERfering and Co-Evolving Prevention and
Therapy (INTERCEPT) program is to explore and evaluate virus-based therapeutic interfering particles (TIPs) that parasitize, interfere, and co-evolve with viral targets as a means of adaptively preventing, controlling, and eliminating acute or chronic infection.
 
INTERCEPT research objectives are structured along three Technical Areas (TAs), to be addressed concurrently:
(1) TIP development and in vitro screening;
(2) TIP optimization and in vitro and in vivo assessment of long-term safety; efficacy, and co-evolution with parent wildtype virus;
(3) mathematical modeling of TIP-pathogen-host dynamics to support TIP optimal design and predict TIP long-term safety, efficacy, co-evolution and co-transmission.
 
Proposers must address one all three Technical Areas OR Technical Areas 2 and 3 OR Technical Area 3.
 
 
Funding: No fixed limit 
Duration: 4 years (in 2 phases) 
 
 
Abstract (encouraged) due date: 19.5.16
Full proposal due date: 7.7.16
 
 
 
 
 
 
 
קבצים מצורפים
קישורלאתר
עדכון אחרוןעדכון אחרון: 01/05/2016
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