AMPt: Autoimmune in Menopause and Pregnancy Transitions

AMPt aims to build immune–endocrine models capable of predicting a woman’s risk of autoimmune onset or flare with enough accuracy to design and deliver effective treatment. 

Thrust Area 1. Measure & model.

Build a dynamic immune endocrine model that forecasts flare and new-onset disease with ≥80% sensitivity and specificity at the postpartum and menopausal transitions, and resolves the immune tolerogenic provocative mechanism per disease.

Thrust Area 2. Predict

Predict flare and new-onset disease across a hormone transition at ≥80% sensitivity and ≥80% specificity, with enough lead time to start disease-modifying and/or hormone timed therapy at least 4 weeks before flares and 12 weeks for new-onset RA.

Thrust Area 3. Intervene

Step in at measured hormone transitions to reduce postpartum flares and slow menopause-associated progression, delivering lactation-safe, hormone-timed protocols.

Funding: No fixed limit 

Duration: 3 years

Research Authority due date: 25.11.26

Abstract (required) due date: 2.12.26

Full proposal due date: 21.1.27