DARPA (DSO): DO Selective Harnessing of Intrinsic Neuroplasticity Engineering (SHINE)

SHINE aims to design, develop, and demonstrate functional biological, chemical, or physical prototype systems capable of inducing circuit-selective neuroplasticity. The program seeks to determine whether adaptive neuroplasticity can be selectively induced within predefined neural substrates while minimizing comparable effects in nontarget tissue.
SHINE seeks enabling methodologies capable of inducing highly specific and adaptive neuroplasticity.
Proposed approaches may employ pharmacologic, biologic, biomaterial, cellular, physical, behavioral, neuromodulatory, or hybrid interventions.
Track A – Accelerated Translation
Track B – Foundational Technology Development

Funding: no fixed limit
Duration: 18 months

Research Authority due date: 4.10.26