CDMRP Neurofibromatosis Research Program: Investigator Initiated Research Award

The Investigator-Initiated Research Award supports highly rigorous, high-impact research projects that have the potential to make an important contribution to NF research and/or patient care. Research projects may focus on any phase of research, excluding clinical trials. Applications must include preliminary and/or published data that are relevant to NF and the proposed research project.

Areas of Emphasis:

• NF2- and schwannomatosis-related areas (e.g., hearing, balance, schwannoma, ependymoma, meningioma, LZTR1, SMARCB1).
• Endpoint validation, biomarker discovery, and technological innovation for assessments
• Application of data science.
• Non-tumor manifestations
• Heterogeneity of NF-related phenotypes.
• Genetics, genomics, epigenetics, systems biology, metabolomics or similar approaches.
• Preclinical efficacy studies.
• Target identification and drug discovery.
• Nutritional, environmental, and other modifiers of NF.
• Health services research

Level 1: Applications without an optional feature.

Level 2: Applications including one of the optional features

It is expected that 7 awards will be granted. 

Funding: Leve 1 $840,000 total. Level 2 $920,000 total 
Duration: 3 years

Research Authority due date: 1.9.26

Pre application (required)  due date: 8.9.26
Full proposal due date: 22.9.26