The Hairy Cell Leukemia Foundation-Leukemia and Lymphoma Society HCL2030

The Hairy Cell Leukemia Foundation (HCLF) and The Leukemia & Lymphoma Society wish to collaborate in targeted research to uncover novel features of classic HCL biology, understand the distinguishing features of HCL variant (“HCLv”) and apply that knowledge in the clinic, translate new medical knowledge to clinical application, test novel treatments in patients through clinical trials, and apply the HCL registry created by HCLF to examine long-term outcomes and quality of life. 

Two grant types will be awarded:

1. Laboratory to Clinical Research Grants (LCRG)

– Projects focused on translational research, including basic research if justified, that has relevance to therapeutic development

– Project led by a single Principal Investigator (PI) but may have one co-PI

– 3 years of support, with the third-year funding dependent on progress assessment at end of year 2

– Cost not to exceed $250,000/year ($750,000 total), including indirect costs 

2. Collaborative Team Grants (CTG)

– Projects focused on the development and implementation of novel clinical trials

– Program activities can include pre-clinical development and correlative studies

– Either one trial with supporting correlative work or multiple projects with related but distinct approaches that contribute to a transformational advance in the treatment of HCL

– Up to 4 investigators (Project Leaders) led by a Program Director (PD)

– Up to 4 years of support

– Cost not to exceed $625,000/yr ($2,500,000 total), including indirect costs; 

Research Authority due date: 14.8.25

LOI  (required) due date: 3.9.25

Full proposal due date: 21.11.25