DARPA (BTO): Broad-Spectrum Antagonists For Editors (B-SAFE)

DARPA is soliciting innovative proposals to identify and optimize novel molecules that exhibit inhibitory effects on Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated proteins (CRISPR-Cas) gene editing processes. The Broad-Spectrum Antagonists for Editors (B-SAFE) program explicitly seeks transformative approaches that enable the discovery or design of novel inhibitors of gene editing technologies with enhanced activity, utility, and breadth of coverage.

Funding: no fixed limit 

Duration: 30 months

Research Authority due date: 8.7.24

Abstract (strongly encouraged) due date: 15.7.24

Full proposal due date: 12.8.24