Provocative Questions (PQs) in Multiple Myeloma Disparities Research (R01)
|קרן||National Cancer Institute/NIH|
|פקולטה||Life Sciences, Medicine|
This grant aims to fund research projects designed to solve specific problems and paradoxes in multiple myeloma (MM) and disparities research identified as the NCI Multiple Myeloma Disparities Provocative Questions (MMD PQs):
MMDPQ1: What risk factors, singularly or in cooperation, explain the variation in monoclonal gammopathy of undetermined significance (MGUS) incidence among different races?
MMDPQ2: What characteristics of immune status and response co-vary with racial/ethnic differences for MGUS incidence, and do these factors influence progression to multiple myeloma?
MMDPQ3: What are the mutational signatures of early onset vs. late onset multiple myelomas across diverse racial/ethnic patient populations?
MMDPQ4: What factors explain the difference in age-adjusted incidence rates for multiple myeloma between males and females? Do these factors play a role in earlier stages of the disease such as MGUS?
MMDPQ5: Can mouse or other preclinical models be developed that accurately reproduce characteristics of the various stages of progression from MGUS to SMM to MM?
MMDPQ6: Are there racial/ethnic differences in the natural history of and response to multiple myeloma therapies including chemotherapy, steroids, targeted therapy, immunotherapy, radiation, and stem cell therapy and, if so, what are the underlying mechanisms
Funding: No fixed limit
Duration: 5 years
Research authority due date: 10 days prior to submission
LOI (encouraged) due dates: 15.6.19, 15.10.19, 15.6.20, 15.10.20
Full proposal 15.7.19, 15.11.19, 15.7.20, 15.11.20
|עדכון אחרון||עדכון אחרון: 14/05/2019|