Cellular Phenotyping in Human iPSCs

This funding program aims to incorporate other molecular and functional phenotypic assays to further characterize the iPSCs/iPSC-derived cells from PPMI. Researchers from public and private institutions are encouraged to apply and to collaborate.

Program Priorities:

• Assessments of known PD targets and pathophysiologic pathways
• Assays to characterize functional, electrophysiological and/or neuroanatomical phenotypes
• Assays/endpoints that can be compared to biofluid data to determine the value of iPSCs as human disease models
• Comparative assessments across different cell types (e.g., neurons, glia)
• Assessments in co-culture systems to study cell autonomous and non-cell-autonomous phenotypes
• Contribution of aging to PD-relevant phenotypes
• Analyses of FOUNDIN-PD data

Funding: 200,000 for analysis of existing datasets; up to $1 million for phenotypic analysis

Duration: 2 years

Research Authority due date: 14.9.21

LOI (required) due date: 28.9.21

Full proposal due date: 13.1.22