Organoid Modeling of Neural Stimulants and HIV Comorbidity of Human Brain (R01)

This grant invites grant applications to study mechanisms underlying the neuropathophysiology of HIV-associated neurological disorders (HAND) using induced microglia and cerebral organoids generated from human derived induced pluripotent stem cell (iPSC) lines. Specific emphasis is on the comorbidity of HIV and neural stimulants, including methamphetamine, amphetamine, cocaine, and nicotine, studied at the single cell and neural circuits levels.

Funding: $500,000 per year 

Duration: 5 years

Research Authority due date: 7.10.21

LOI (encouraged) due date: 17.10.21

Full proposal due date: 17.11.21